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Example calculation for a standard-concentration MIC B12 vial: Vial label: Methionine 25 mg/mL Inositol 50 mg/mL Choline 50 mg/mL Cyanocobalamin 1,000 mcg/mL Prescribed dose: 1 mL weekly Actual intake per injection: Methionine: 25 mg Inositol: 50 mg Choline: 50 mg Vitamin B12: 1,000 mcg (1 mg) Now compare this to dietary intake and established adequate intake levels: Methionine: The average American diet provides 2,000-3,000 mg of methionine per day (Brosnan et al., Journal of Nutrition , 2006)

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doi: 10.2174/1568026622666220428095250 20 CavaleriDBartoliFCapogrossoCAGuzziPMorettiFRiboldiIet al